ATTENUATION OF PARAQUAT TOXICITY IN MICE

attenuation of paraquat toxicity in mice

paraquat (pq) is a widely used herbicide. however, a large number of cases of accidental or suicidal poisoning from pq has been reported. membrane damage induced by lipid peroxidation, inactivation of protein or damage to dna by radical formation have been suggested as toxicity mechanisms of pq. in the present work, the effects of atropine, propranolol, procainamide and dipyridamole on pq-induc...

Paraquat Induced Toxicity in Adrenals in Albino Mice

Objectives: The current study aims to observe the histological effects of paraquat on the adrenal Glands of the mice after single exposure to sub-lethal dose of the drug. Materials and Method: Forty male mice, fifteen control (group I) and twenty-five experimental (group II) were used. Each experimental animal (group II) was given a single dose of paraquat i.e 20 mg/kg dissolved in 0.2 ml norma...

The toxicity of paraquat.

Toxicity of paraquat to microorganisms.

The biochemical response of the microorganisms Lipomyces starkeyi (Lod & Rij), Escherichia coli K-12 W3110, Bacillus subtilis 168 (Marburg) and Pseudomonas sp. strain TTO1 to the presence of growth-inhibitory concentrations of paraquat was studied. Paraquat was added to each culture at a concentration previously determined to reduce the culture growth rate by up to 50%. The changes in activity ...

The Effect of Rebadioside A on Attenuation of Oxidative Stress in ‎Kidney of Mice under Acetaminophen Toxicity

Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is ‎also believed that oxidative stress has a pivotal role in APAP-induced renal injury. ‎Therefore, protective effects of different antioxidants have been examined in APAP-‎induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. T...

Evidence of Oxidative Damage in Paraquat Toxicity

Article history: Received: 7 Mar 2013 Accepted: 29 May 2013 Available online: 30 Nov 2013 ZJRMS 2014 Dec; 16(12): 1-7 The herbicide parquet (1, 1-dimethyl-4, 4-bipyridilium dichloride; PQ) is a highly toxic quaternary nitrogen herbicide. Many cases of PQ acute poisoning and death have been reported over the past few decades. The mechanisms of PQ toxicity have been reported to involve the genera...